Histo- and morphometric changes in the large intestine mucosa in Crohn’s disease depending on the presence of fibrosis

Background. One of the common complications Crohn’s disease is development fibrotic changes in wall large intestine, and, as a result, risk strictures. Morphometric study cellular composition intestine ­biopsy samples one extended links diagnostic criteria for inflammatory bowel diseases, which make it possible to predict disease. Changes number fibroblasts, components mesenchymal cells, can be considered protective reaction intestinal tissue damage. The purpose was reveal histo- and morphometric parame­ters mucosa depending on fibrosis Materials methods. Colon biopsy from patients with (n = 38) were examined histologically morphometrically. According morphological studies, divided into two groups: 10) without 28). Results. Histologically, observed form altered integrity epithelium (78.3 %), crypt architectonics (34.2 mucosal edema (28.9 abscesses (47.3 %). Fibrotic found 26.3 % patients. infiltrate contained neutrophils, eosinophils, lymphocytes, plasma fibrocytes, macrophages. At same time, group fibrosis, representatives higher than fibrosis. Patients characterized by density dominated macrophages fibroblasts. Thickening also cause such activation mechanism against background processes. Direct correlations between colon depth crypts (r 0.35; p < 0.05), height 0.41; 0.45; neutrophils 0.47; eosinophils 0.39; fibroblasts 0.57; 0.05). Conclusions. In denser increased level noted. active process directly related high infiltrate.